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Preliminary Clinical Trial Shows Grapeseed Extract in Moxxor Reduces Exercise-Induced Oxidative Stress

(NaturalNews) A preliminary clinical trial has been completed by Dr. Glenn Vile in conjunction with HortResearch, a New Zealand research institution. Although the number of participants in the trial is small (eleven competitive rowers), the double-blind nature of the trial and the preliminary results indicate that the grapeseed extract used in Moxxor (a marine omega-3 nutritional supplement) may be beneficial as a dietary supplement for helping reduce oxidative stress during exercise.

Here's how the trial was structured: One hour prior to exercise, competitive rowers were given either 150mg of grapeseed extract (GSE) or 150mg of placebo (glucose). A second dose of the same amount was given after the 30-minute exercise session. Blood samples were taken one hour prior to exercise and one hour after exercise.

The blood samples were analyzed to determine the level of lactate dehydrogenase (LDH), a chemical marker of oxidative stress and muscle damage. The results of this preliminary trial reveal that those rowers who took the grapeseed extract used in Moxxor experienced a 34% reduction in LDH levels (plus or minus 6%).

The author's conclusion of this study is included below, along with full references.

While the study was too small to support sweeping generalizations about GSE and exercise for the population as a whole, it does provide justified optimism for further study of grapeseed extract as potential reducer of exercise-induced oxidative stress. This may mean (although there is no proof of this yet) that GSE might also be a useful element to study in the prevention of heart disease or cancer. Recent laboratory research conducted at the University of Kentucky, in fact, reveals that GSE causes leukemia cells to commit suicide (apoptosis), thereby positioning grapeseed extract as a potentially useful anti-cancer element for further study.

If you are interested in taking Moxxor, by the way, there are currently over 1,000 NaturalNews readers who are Moxxor members, and they can introduce you to the remarkable health properties of this marine omega-3 oil that contains grapeseed extract from New Zealand. Simply go to www.NaturalNews.com/Moxxor-information.html and click on the city nearest you to find a NaturalNews Moxxor team member. Then contact them by phone or email to learn more.

You can also read more about the science behind Moxxor's anti-inflammatory properties here: www.NaturalNews.com/moxxor_health_benefits.asp

Note: This article makes no health claims about Moxxor, and Moxxor is not intended to diagnose, treat or prevent any disease. I have a financial stake in the success of Moxxor, and I currently take six to eight capsules of Moxxor each day. It should also be noted that Dr. Glenn Vile has a financial stake in the success of grapeseed extract, as he is one of the founders of New Zealand Extracts, which you can read about here: http://www.stuff.co.nz/4241346a13.html

The company's grapeseed products are described here (very interesting reading): http://www.nzextracts.co.nz/grapeseed.htm

It's also worth noting that the grapeseed extract used in this study is the exact same grapeseed extract used in Moxxor.

MOXXOR Antioxidant and Exercise
Here's the text of the preliminary study from Dr. Glenn Vile:

The increased demand for energy during exercise requires an increased oxygen supply to active tissues and an increased metabolic rate. Based on our current understanding that there is a balance between oxidative stress and our antioxidant defense mechanisms it would be predicted that the increased oxygen supply and metabolic rate associated with exercise would overwhelm our antioxidant defense mechanisms and lead to increased levels of oxidative stress. There is good evidence that is the case. Oxidative damage to lipids, proteins, and DNA occurs in both trained and untrained volunteers during, and for up to 24hrs after, taking part in activities such as alpine ski racing, long distance running, and cycling (Shing et al 2007, Subudhi et al 2001, Mastaloudis et al 2001, Ramel et al 2004, Aguilo et al 2005, Goldfarb et al 2005 and Itoh H et al 2000).

Antioxidants, particularly vitamin E, are depleted during exercise (Mastaloudis et al 2001 and Aguilo et al 2005), and recent evidence suggests that the dietary intake of antioxidants by athletes is lower than the general population (Machefer et al 2007). Supplementation with antioxidants prior to exercising reduces the oxidative damage that occurs during exercise. Antioxidants that have been shown to be effective include vitamins E and/or C (Aguilo et al 2005, Goldfarb et al 2005, Itoh et al 2000, Bryant et al 2004 and Bloomer et al 2004), and polyphenolic compounds of the type that are found in Grape Seed Extract (Morillis et al 2005, Pilaczynska-Szczesniak et al 2005 and Murase et al 2005). In addition antioxidant supplementation enhances aerobic performance in athletes (Aguilo et al 2007).

A daily dose of 35-110 mg of polyphenolic compounds, such as those found in MOXXOR Grape Seed Extract, has been shown to be effective in reducing oxidative damage and preventing the depletion of vitamin E that occurs during normal and strenuous levels of activity (Pilaczynska-Szczesniak et al 2005, Murase et al 2005 and Simonetti et al 2002).

Antioxidant supplementation prior to exercise has been shown to decrease some of the unwanted consequences of exercise e.g. muscle soreness (Bloomer et al 2004) but at this stage there is no evidence that antioxidant supplementation improves exercise performance (Itoh et al 2000 and Bloomer et al 2004).

The high antioxidant activity of MOXXOR grape seed extract has been demonstrated in test tube assays (Oxygen Radical Absorbance Capacity or ORAC assays) and in cytoprotection assays with cultured human cells.

In order to determine if MOXXOR grape seed extract is able to protect athletes from muscle damage that occurs as a consequence of the increased levels of oxidative stress generated during exercise, MOXXOR in conjunction with HortResearch, a New Zealand research institution, have performed a preliminary clinical trial.

Eleven well trained rowers completed a full cross-over trial. One hour prior to a 30 min maximal rowing ergo-meter test the participants were given a capsule containing either 150mg of MOXXOR grape seed extract or 150mg of glucose (a placebo, and a double blind cross-over trial). A second capsule of 150 mg was given immediately post-exercise bringing the total dose to 300mg. Blood samples were taken one hour prior to exercise and one hour after exercise and lactate dehydrogenase (LDH) was measured in plasma samples as an indicator of muscle damage.

As expected, levels of LDH significantly increased in the blood one hour following the rowing ergo-meter exercise. An acute total dose of 300mg of MOXXOR grape seed extract decreased the release of LDH by 34 +/-6%. The results of this preliminary trial indicate that MOXXOR grape seed extract may be effective at reducing the muscle damage that occurs in trained athletes following exercise.

References

Aguilo A, Tauler P, Fuentespina E, Tur JA, Cordova A, and Pons A (2005). Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol Behav 31:1-7.

Aguilo A, Tauler P, Sureda A, Cases N, Pons A (2007). Antioxidant diet supplementation enhances aerobic performance in amateur sports men. J. Sports Sci. 25:1203-1210.

Bloomer RJ, Goldfarb AH, McKenzie MJ, You T and Nguyen L (2004). Effects of antioxidant therapy in women exposed to eccentric exercise. Int J Sport Nutr Exerc Metab 14:377-388.

Bryant RJ, Ryder J, Martino P, Kim J and Craig BW (2003). Effects of vitamin C and E supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Con Res 17:792-800.

Goldfarb AH, Bloomer RJ and McKenzie MJ (2005). Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise. Med Sci Sports Exerc 37: 234-239.

Itoh H, Ohkuwa T, Yamazaki, Shimoda T, Wakayma A, Tamura S, Yamamoto T, Sato Y and Miyamura M (2000). Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Int J Sports Med 21:369-374.

Machefer G, Groussard C, Zouhal H, Vincent S, Youssef H, Faure H, Malarde L, Gratas-Delamarche A (2007). Nutritional and plasmatic antioxidant vitamins status of ultra endurance athletes. J Am Coll Nutr 26:311-316.

Mastaloudis A, Leonard SW and Traber MG (2001). Oxidative stress during extreme endurance exercise. Free Radic Biol Med 31:911-922.

Grapeseed Extract Kills 76% of Leukemia Cancer Cells in 24 Hours

(NaturalNews) A new study conducted at the University of Kentucky in the United States, and published in the journal Clinical Cancer Research, found that leukemia cancer cells exposed to grapeseed extract (GSE) were rapidly killed through a process of cell suicide known as "apoptosis."

In these laboratory studies, an astonishing 76% of leukemia cells committed suicide within 24 hours thanks to the ability of GSE to activate a protein called JNK, which regulates apoptosis.

In a healthy person, cancer cell apoptosis is a normal, healthy part of biology. Every living system creates cancerous cells. There are hundreds or thousands of "microtumors" in every human being living today, but cancerous cells in healthy people destroy themselves once they realize they're flawed. This cellular "realization," however, requires healthy cell communication, and that's dependent on the correct nutrients, minerals and proteins being available in the body.

Grapeseed extract appears to accelerate this process in cancer cells, helping them more rapidly assess their own flawed state so they can engage in apoptosis (cell suicide), thus protecting the larger organism (the body).

It's important to note that this recent study was conducted in a lab, not in human beings, so its conclusions cannot necessarily be directly translated into saying something like "grapeseed extract cures cancer," for example. However, it does indicate quite convincingly that if the unique phytochemical molecules found in grapeseed extract can be delivered to leukemia cells with sufficient potency, they may play an important role in cancer cells destroying themselves, thereby protecting the whole organism from runaway cancer.

If the results demonstrated in the labs at the University of Kentucky can be replicated in humans, it could potentially position grapeseed extract as one of the most powerful natural chemotherapeutic agents yet discovered.

Grapeseed extract has been studied and demonstrated to be remarkably effective at killing cancer cells for many different types of cancer, by the way, including cancers of the breast, prostate, lung, skin bowel and stomach.

Eat more grapes?
The conventional cancer community, of course, is quick to warn people not to simply eat more grapes in the hopes that grapeseed extract will help prevent their cancer. But I ask, "Why not?" Unlike toxic chemotherapy, eating grapes has zero negative side effects. At the same time, grapes offer numerous other health benefits, since they are a source of resveratrol and various protective phytonutrients.

Of course, you have to eat grapes with seeds in them, and since the global food supply has become so distorted over the past few years, it's difficult to find grapes with seeds in them. My advice? Buy your grapes from a health food store: Look for organic, seeded grapes. And when you eat them, don't spit out the seeds (obviously). Chew them up, and you'll digest the grapeseed extract that's naturally present in those seeds.

I've talked with conspiracy theorists who believe the seeds were purposely taken out of the grapes in the national food supply for precisely this reason (to remove the anti-cancer nutrients from food, thus keeping people sick). I disagree with that explanation, however: Seedless grapes are simply a product of consumer demand, in much the same way that consumers prefer seedless watermelon. If consumers actually knew about the health benefits of grape seeds, they might think differently, but thanks to efforts by the FDA and USDA, the mainstream public has remained virtually illiterate on nutrition for several decades, and you'll rarely meet an individual who is aware that eating grape seeds is actually good for you.

Don't be fooled by the cereal Grape Nuts, by the way. That's just a clever name. The cereal contains no grape seeds whatsoever. (It's made from roasted barley and other grains.)

Protecting healthy cells
Another important finding in the University of Kentucky study is that the grapeseed extract was not toxic to normal, healthy cells even as it helped cancer cells commit suicide.

This is hugely important because it shows, yet again, that Mother Nature's medicine is far safer than medicine created by Man. Conventional chemotherapy chemicals are extremely toxic to healthy cells, which is why chemotherapy causes permanent brain damage ("chemo brain"), kidney damage and heart damage. Grapeseed extract, however, causes no such damage, and there has never been a person who died from eating grapes. (There have been millions, probably, who were killed by chemotherapy.)

As Professor Xianglin Shi, the lead researcher of the study, said in a BBC article: "These results could have implications for the incorporation of agents such as grapeseed extract into prevention or treatment of haematological (blood) malignancies and possibly other cancers. ...What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grapeseed extract fits into this category."

In other words, grapeseed extract is now a candidate for a natural chemotherapeutic agent.

Grapeseed extract and endurance
The benefits of grapeseed extract don't stop with its anti-cancer potential, by the way: The antioxidant is also known to be extremely effective at reducing oxidative stress during exercise.

I posted another article today about the results of a fascinating preliminary clinical trial using grapeseed extract, the antioxidant used in Moxxor (which is a premium marine omega-3 oil supplement that contains grapeseed extract as one of its three ingredients).

The results of that clinical trial are extremely promising in showing that the grapeseed extract used in Moxxor may help reduce the level of oxidative stress experienced during exercise. This trial was conducted by Dr. Glenn Vile in conjunction with HortResearch, a New Zealand research institution.

This preliminary trial was conducted on competitive boat rowers who were given GSE one hour before engaging in vigorous exercise. (The trial was structured as a double-blind, randomized cross-over trial using placebo.) Results indicate that the rowers given GSE experienced a significant reduction of lactate dehydrogenase (LDH), a chemical marker for exercise-induced oxidative stress. The reduction level was 34% + / - 6%

You can read more about that clinical trial here: http://www.naturalnews.com/025247.html

In all, this is fantastic news about grapeseed extract, as it demonstrates the ability of this natural substance to kill cancer cells in the lab. Given that grapes are a safe and customary part of the food supply, and that grapes are naturally intended to contain seeds, it seems quite sensible to conclude that human beings were intended to eat grape seeds and derive health benefits from them. Buy more (seeded) grapes!

If you're interested in Moxxor, by the way, there are currently over 1,000 NaturalNews readers who are Moxxor members, and they can introduce you to the product. Simply go to www.NaturalNews.com/Moxxor-information.html and click on the city nearest you to find a NaturalNews Moxxor team member. Or read more about the science behind Moxxor's anti-inflammatory properties here: www.NaturalNews.com/moxxor_health_benefits.asp

Note: This article makes no health claims about Moxxor, and Moxxor is not intended to diagnose, treat or prevent any disease. I have a financial stake in the success of Moxxor, and I currently take six to eight capsules of Moxxor each day.

Grapeseed extract is also available as a nutritional supplement from numerous sources, but one thing you'll notice about GSE in supplement form is that the actual nutrient is so tiny that most of the GSE supplements contain a lot of filler (silica, stearic acid, silicon dioxide, etc.). I've recently become more concerned about the cumulative levels of consumption of supplement fillers by people who take a lot of nutritional supplements, and I'm personally reducing my consumption of supplement pills while increasing my consumption of superfood-based powders and fresh product.

The best way to get grapeseed extract is by eating grape seeds. The second best way is to get it mixed in with a superfood powder or supplement that contains no filler. The least preferred way to get it is by taking a GSE capsule made with a lot of filler, so keep that in mind.